Translating biomedical scientific discoveries into policy and practice has been a major challenge in the U.S. This has led to large gaps in major vital heath statistics across population groups and poorer overall health compared to peer nations. The factors driving this disconnect fall both within and outside the domains of traditional academic medicine. The former includes suboptimal integration of biomedical and population health disciplines, a pitfall that plagues most academic medical centers. The latter includes social, political, and economic considerations that are beyond the reaches of academic medicine. The University of Chicago has tremendous potential with regard to addressing these challenges. This can be accomplished through an integrative research, partnership, translation and implementation across the disciplinary boundaries and sectors.